Electrochemistry Research Scientist permanent full time positionsup to £21,000 £35,000 per annum dependant on experience2 positions available one suitable for graduate entryOxford basedAre you either...
Job Title - Biomedical Research Engineer
Location - London
Salary - £30,000 - £40,000
Advert posted on: 30 May 2018
Advert closing date: 22 June 2018
DNAe, the inventors of semiconductor-based next-generation sequencing (NGS) technology, is developing a revolutionary new platform that enables NGS-based diagnostic capability in an easy to use, cartridge-based system that will allow direct from clinical specimen to clinically relevant, actionable results in a matter of hours.
DNAe are currently looking to hire additional outstanding talent to join the existing multi-disciplinary NGS platform development team, filling key roles in the rapidly expanding program. The specific role described here is biomedical research engineer for the cartridge subsystem of the NGS workflow.
The successful candidate will be integrating the chemistry workflow onto the cartridge of an NGS platform using results of scientific research. The candidate will lead experimental studies into parameter optimisation to feed into cartridge design, using a broad knowledge of both the science and engineering workflows. The successful candidate will work closely with the Instrument, Chemistry Workflow and Integrated Circuit Groups.The biomedical research engineer will contribute to the development of a commercial, integrated diagnostic device, including the required documentation in accordance with ISO 13485 certified quality management system, reporting (both written and verbal) and successful completion of deliverables in a timely manner. They will also be a creative individual who is comfortable contributing to multi-disciplinary teams of scientists and engineers, is commercially aware, and uses strong technical expertise to liaise with internal and external customers as well as international suppliers.As a biomedical research engineer, your activities in general will be:
- Design, plan and conduct laboratory experiments to understand and optimise physical, electrical and chemical parameters for cartridge-based biochemistry processes
- Devise and apply novel methodologies and techniques to enable effective testing
- Compile, analyse and interpret experimental results and data, and form conclusions to determine optimal conditions and design requirements
- Conceive, design and test systems, components and processes to meet product requirements from internal and external customers
- Record, document, and present summarised results to internal and external stakeholders
- Provide technical advice on integration of science and engineering related aspects of NGS platform
- Support the manufacture, development and testing of design prototypes
DNAe are looking for people with drive, enthusiasm and a strong work ethic who desire to play a key role in the creation of a paradigm shifting platform that will have major impact on the health and wellbeing of patients around the world. The successful candidate must have the ability to conduct informative research and deliver effective solutions to challenging problems in a fast-paced environment with adherence to tight timelines.
Further, the successful candidate must be a team player who interacts well with a variety of colleagues within and outside their area of expertise, manages team members effectively, is a strong and proactive communicator and is willing to step in and take on additional responsibilities as they arise, even those outside the normal scope of responsibilities, in order to help achieve timely success of the project.
Qualifications & Experience
- Higher degree in biomedical engineering, or equivalent employment experience, with knowledge of microfluidics, electrical engineering, analytics and life sciences
- Demonstrable commercial experience in a new product development environment for IVD devices within the field of next generation sequencing
- Practical experience of semi-conductor based ISFET signal detection applied to NGS biological assays
- Background in both medical/biological research and engineering design and research
- Experience with planning and performing scientific experiments to understand and optimise conditions for an NGS workflow, and to verify and validate design decisions
- Ability to utilise knowledge of microfluidics, pneumatics, fluid control, temperature control, and sensor integration to inform the design of components for an NGS platform
- Understanding of and experience with physical, chemical and electrical parameters within the context of molecular biological assays (for example: pH, mixing, temperature, flow rate, microfluidic behaviour, surface conditions)
- Proven ability to analyse results and data to reach conclusions, particularly by using Matlab
- Experience using laboratory notebooks, completing technical QC documentation and working in an ISO 13485:2012 regulated organization
- Ability to communicate experimental results and technical knowledge in a clear and understandable manner to internal and external stakeholders
- Knowledge of change control processes and good practices
- Experience with 2D and 3D engineering design and manufacturing tools (specifically SolidWorks 2016)
- Proven ability to operate and practical experience with CNC milling, rapid prototyping techniques (3D printing), laser cutting, plastic bonding techniques
- Experience of design and testing of sealed fluidic plastic parts for demanding thermal applications (e.g. PCR thermocycling)
- Knowledge of, and ability to write machine programs using scripting languages (specifically Lua) and feedback loop control applied to instruments
The recruiter has stated that all applicants for this job should be able to prove they are legally entitled to work in the UK. SRG is a trading name of Science Recruitment Group Ltd an Employment Business/Agency.