Surface Chemist - Molecular Diagnostics

Job Ref: J28244
Sector: Science
Sub-sector: Biotech/Life Sciences
Job Type: Permanent
Date Added: 07 May 2019
  • London, England, UK London London UK W1 1AA
  • Competitive
  • Neil Walton
  • 0203 096 4700

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Surface Chemist - Molecular Diagnostics

Competitive Salary commensurate with experience

London Based

Do you have experience in developing surface attachment chemistries related to the immobilisation of biomolecules e.g. nucleic acids, proteins, enzymes?

Would you like to work for a cutting-edge molecular diagnostics company in London?

My client, the inventors of semiconductor-based next-generation sequencing (NGS) technology, are developing a revolutionary new NGS-based diagnostic platform in an easy-to-use, cartridge-based system designed to generate a clinically actionable result direct from clinical specimen, in a matter of hours.

They are looking to hire a Surface Chemist to work with the Next Generation Sequencing (NGS) development team and will be responsible for a subset of the team deliverables, comprising technology development of a massively parallel sequencing process performed on an integrated circuit (chip). The on-chip process must be compatible with cartridge-based automation and performance must meet the demanding requirements of the novel NGS platform.

Specific responsibilities of the Surface Chemist include;

  • Development of new and novel functionalized surfaces for use in the Next-Generation Sequencing platform
  • Design and execution of laboratory experiments and in-depth analysis of resulting data
  • Interfacing with external partners to develop key platform components
  • Management of the work of 1-2 Research Assistants.
  • Literature (including patent) work to support development of the technology
  • Proactive interaction with other NGS platform teams to assure effective communication and proper alignment of input/output requirements
  • Participation in the integration of the technology into the automated platform
  • Generation and management of all required documentation and presentation of results

Person Specification

We are looking for people with drive, enthusiasm and a rock-solid work ethic who strongly desire to play a key role in the creation of a paradigm shifting platform that will have major impact on the health and wellbeing of patients around the world. The successful candidate must have the ability to deliver effective solutions to challenging problems in a fast paced environment with adherence to tight timelines.

Further, the successful candidate must be a team player who interacts well with a variety of colleagues within and outside their area of expertise, manages direct reports effectively, is a strong and proactive communicator and is willing to step in and take on additional responsibilities as they arise, even those outside the normal scope of responsibilities, in order to help achieve timely success of the project.

Qualifications and experience


  • PhD (preferred) or MSc in Chemistry, Biochemistry, materials science or related field
  • Experience developing surface attachment chemistries related to the immobilisation of biomolecules (e.g. nucleic acids, proteins, enzymes) ideally as a part of an NGS workflow, IVD device, or microarray technology
  • Experience with nucleic acid amplification (PCR or non-PCR, such as isothermal), including solid-phase amplification methods
  • Experience developing methods for surface characterisation and using techniques such as XPS, dynamic light scattering, SEM, and fluorescence microscopy
  • Excellent problem solving and analytical skills
  • Excellent administrative, organisational, communication and interpersonal skills


  • Industry experience in the development of molecular IVD technology for commercially relevant applications, particularly NGS-based products
  • Assay integration experience, including reagent stabilisation
  • Experience managing small teams of technicians and/or Research Assistants
  • Demonstrable creativity and innovation (e.g. as evidenced by patent filings and allowances and/or scientific publications)

Key Words "Surface Chemist, Bioconjugation, conjugation, immobilisation, XPS, SEM, Fluorescence microscopy, microarray, isothermal, PCR, IVD amplification"

To be considered for this role, please apply online or call Neil Walton on 02030964706.

06/06/2019 17:57:02